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Osteoarthritis, hand(HOA)

MedGen UID:
472992
•Concept ID:
C0263746
•
Disease or Syndrome
Synonyms: Hand osteoarthritis; HAND OSTEOARTHRITIS; HOA
SNOMED CT: Osteoarthritis - hand joint (22193007); Osteoarthrosis of hand (22193007); Degenerative joint disease of hand (22193007)
 
Monarch Initiative: MONDO:0006632
OMIM®: 140600

Definition

Osteoarthritis of the hands usually happens as part of nodal osteoarthritis (a form of osteoarthritis that runs in families). This mainly affects women and often starts in your 40s or 50s, around the menopause (the time when menstruation ends and it’s no longer possible to have children). [from MONDO]

Professional guidelines

PubMed

Pharmaceutical treatment of osteoarthritis.
Richard MJ, Driban JB, McAlindon TE
Osteoarthritis Cartilage 2023 Apr;31(4):458-466. Epub 2022 Nov 19 doi: 10.1016/j.joca.2022.11.005. PMID: 36414224
2018 update of the EULAR recommendations for the management of hand osteoarthritis.
Kloppenburg M, Kroon FP, Blanco FJ, Doherty M, Dziedzic KS, Greibrokk E, Haugen IK, Herrero-Beaumont G, Jonsson H, Kjeken I, Maheu E, Ramonda R, Ritt MJ, Smeets W, Smolen JS, Stamm TA, Szekanecz Z, Wittoek R, Carmona L
Ann Rheum Dis 2019 Jan;78(1):16-24. Epub 2018 Aug 28 doi: 10.1136/annrheumdis-2018-213826. PMID: 30154087
Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management.
Marshall M, Watt FE, Vincent TL, Dziedzic K
Nat Rev Rheumatol 2018 Nov;14(11):641-656. doi: 10.1038/s41584-018-0095-4. PMID: 30305701

Curated

UK NICE Guideline NG226, Osteoarthritis in over 16s: diagnosis and management, 2022

Recent clinical studies

Etiology

Burden of osteoarthritis in China, 1990-2019: findings from the Global Burden of Disease Study 2019.
Li H, Kong W, Liang Y, Sun H
Clin Rheumatol 2024 Mar;43(3):1189-1197. Epub 2024 Jan 30 doi: 10.1007/s10067-024-06885-9. PMID: 38289570Free PMC Article
Efficacy and safety of acupuncture for hand osteoarthritis: study protocol for a multi-center, randomized, sham-controlled clinical trial.
Wang W, Shi H, Liu Y, Sun Y, Chen Y, Liu Z
J Orthop Surg Res 2023 Feb 6;18(1):89. doi: 10.1186/s13018-023-03570-6. PMID: 36747297Free PMC Article
Efficacy of corticosteroids for hand osteoarthritis - a systematic review and meta-analysis of randomized controlled trials.
Estee MM, Cicuttini FM, Page MJ, Butala AD, Wluka AE, Hussain SM, Wang Y
BMC Musculoskelet Disord 2022 Jul 13;23(1):665. doi: 10.1186/s12891-022-05619-9. PMID: 35831847Free PMC Article
Current Epidemiology and Risk Factors for the Development of Hand Osteoarthritis.
Plotz B, Bomfim F, Sohail MA, Samuels J
Curr Rheumatol Rep 2021 Jul 3;23(8):61. doi: 10.1007/s11926-021-01025-7. PMID: 34216294
Osteoarthritis in the Middle-Aged and Elderly in China: Prevalence and Influencing Factors.
Sun X, Zhen X, Hu X, Li Y, Gu S, Gu Y, Dong H
Int J Environ Res Public Health 2019 Nov 26;16(23) doi: 10.3390/ijerph16234701. PMID: 31779104Free PMC Article

Diagnosis

Determination and characterization of patient subgroups based on pain trajectories in hand osteoarthritis.
van der Meulen C, van de Stadt LA, Rosendaal FR, Runhaar J, Kloppenburg M
Rheumatology (Oxford) 2023 Sep 1;62(9):3035-3042. doi: 10.1093/rheumatology/kead017. PMID: 36648311Free PMC Article
Associations of Body Mass Index With Pain and the Mediating Role of Inflammatory Biomarkers in People With Hand Osteoarthritis.
Gløersen M, Steen Pettersen P, Neogi T, Jafarzadeh SR, Vistnes M, Thudium CS, Bay-Jensen AC, Sexton J, Kvien TK, Hammer HB, Haugen IK
Arthritis Rheumatol 2022 May;74(5):810-817. Epub 2022 Mar 23 doi: 10.1002/art.42056. PMID: 35137553Free PMC Article
Topical corticosteroid for treatment of hand osteoarthritis: study protocol for a randomised controlled trial.
Wang Y, Hussain SM, Gan D, Lim YZ, Estee MM, Heritier S, Wluka AE, Cicuttini FM
BMC Musculoskelet Disord 2021 Dec 13;22(1):1036. doi: 10.1186/s12891-021-04921-2. PMID: 34903211Free PMC Article
Aesthetic discomfort in hand osteoarthritis: results from the LIège Hand Osteoarthritis Cohort (LIHOC).
Neuprez A, Bruyère O, Maheu E, Dardenne N, Burlet N, D'Hooghe P, Distèche S, Reginster JY
Arthritis Res Ther 2015 Nov 30;17:346. doi: 10.1186/s13075-015-0807-y. PMID: 26620999Free PMC Article
Clinical and radiographic disease course of hand osteoarthritis and determinants of outcome after 6 years.
Bijsterbosch J, Watt I, Meulenbelt I, Rosendaal FR, Huizinga TW, Kloppenburg M
Ann Rheum Dis 2011 Jan;70(1):68-73. Epub 2010 Aug 24 doi: 10.1136/ard.2010.133017. PMID: 20736393

Therapy

Efficacy and safety of acupuncture for hand osteoarthritis: study protocol for a multi-center, randomized, sham-controlled clinical trial.
Wang W, Shi H, Liu Y, Sun Y, Chen Y, Liu Z
J Orthop Surg Res 2023 Feb 6;18(1):89. doi: 10.1186/s13018-023-03570-6. PMID: 36747297Free PMC Article
Efficacy of corticosteroids for hand osteoarthritis - a systematic review and meta-analysis of randomized controlled trials.
Estee MM, Cicuttini FM, Page MJ, Butala AD, Wluka AE, Hussain SM, Wang Y
BMC Musculoskelet Disord 2022 Jul 13;23(1):665. doi: 10.1186/s12891-022-05619-9. PMID: 35831847Free PMC Article
Comparison of the effectiveness of peloid and paraffin treatment for symptomatic hand osteoarthritis in women: a single-blind randomized controlled study.
Aksanyar B, Yılmaz H, Karaarslan F, Yılmaz R, Karpuz S
Int J Biometeorol 2022 Aug;66(9):1841-1851. Epub 2022 Jul 6 doi: 10.1007/s00484-022-02324-z. PMID: 35794487Free PMC Article
Topical corticosteroid for treatment of hand osteoarthritis: study protocol for a randomised controlled trial.
Wang Y, Hussain SM, Gan D, Lim YZ, Estee MM, Heritier S, Wluka AE, Cicuttini FM
BMC Musculoskelet Disord 2021 Dec 13;22(1):1036. doi: 10.1186/s12891-021-04921-2. PMID: 34903211Free PMC Article
Efficacy of paraffin bath therapy in hand osteoarthritis: a single-blinded randomized controlled trial.
Dilek B, Gözüm M, Şahin E, Baydar M, Ergör G, El O, Bircan Ç, Gülbahar S
Arch Phys Med Rehabil 2013 Apr;94(4):642-9. Epub 2012 Nov 24 doi: 10.1016/j.apmr.2012.11.024. PMID: 23187044

Prognosis

Burden of osteoarthritis in China, 1990-2019: findings from the Global Burden of Disease Study 2019.
Li H, Kong W, Liang Y, Sun H
Clin Rheumatol 2024 Mar;43(3):1189-1197. Epub 2024 Jan 30 doi: 10.1007/s10067-024-06885-9. PMID: 38289570Free PMC Article
The Association of AUSCAN and PRWHE Patient-reported Outcome Measures With Radiographic Progression of Early Thumb Carpometacarpal Arthritis at 36-Month Follow-up Is Limited to Subtle Changes in the Pain Subscale.
Gil JA, Kleiner J, McQuillan TJ, Kenney D, Ladd AL, Weiss AC, Crisco JJ
Hand (N Y) 2022 Mar;17(2):354-360. Epub 2020 Sep 16 doi: 10.1177/1558944720928489. PMID: 32935579Free PMC Article
The presence of erosive joints is a strong predictor of radiological progression in hand osteoarthritis: results of a 2-year prospective follow-up of the Liège Hand Osteoarthritis Cohort (LIHOC).
Neuprez A, Kaux JF, Locquet M, Beaudart C, Reginster JY
Arthritis Res Ther 2021 Jan 6;23(1):12. doi: 10.1186/s13075-020-02390-x. PMID: 33407767Free PMC Article
Clinical and radiographic disease course of hand osteoarthritis and determinants of outcome after 6 years.
Bijsterbosch J, Watt I, Meulenbelt I, Rosendaal FR, Huizinga TW, Kloppenburg M
Ann Rheum Dis 2011 Jan;70(1):68-73. Epub 2010 Aug 24 doi: 10.1136/ard.2010.133017. PMID: 20736393
Progression of hand osteoarthritis over 2 years: a clinical and radiological follow-up study.
Botha-Scheepers S, Riyazi N, Watt I, Rosendaal FR, Slagboom E, Bellamy N, Breedveld FC, Kloppenburg M
Ann Rheum Dis 2009 Aug;68(8):1260-4. Epub 2008 Aug 26 doi: 10.1136/ard.2008.087981. PMID: 18728047

Clinical prediction guides

Determination and characterization of patient subgroups based on pain trajectories in hand osteoarthritis.
van der Meulen C, van de Stadt LA, Rosendaal FR, Runhaar J, Kloppenburg M
Rheumatology (Oxford) 2023 Sep 1;62(9):3035-3042. doi: 10.1093/rheumatology/kead017. PMID: 36648311Free PMC Article
The High Clinical Burden of Erosive Hand Osteoarthritis is Associated with Clinical Findings, Pain, and Radiographic Severity.
Duarte-Salazar C, Marín-Arriaga N, Miranda-Duarte A
Reumatol Clin (Engl Ed) 2022 Jun-Jul;18(6):338-342. doi: 10.1016/j.reumae.2021.03.009. PMID: 35680365
The clinical and cost effectiveness of splints for thumb base osteoarthritis: a randomized controlled clinical trial.
Adams J, Barratt P, Rombach I, Arden N, Barbosa Bouças S, Bradley S, Doherty M, Dutton SJ, Gooberman-Hill R, Hislop-Lennie K, Hutt-Greenyer C, Jansen V, Luengo-Fernadez R, Williams M, Dziedzic K
Rheumatology (Oxford) 2021 Jun 18;60(6):2862-2877. doi: 10.1093/rheumatology/keaa726. PMID: 33254239
Aesthetic discomfort in hand osteoarthritis: results from the LIège Hand Osteoarthritis Cohort (LIHOC).
Neuprez A, Bruyère O, Maheu E, Dardenne N, Burlet N, D'Hooghe P, Distèche S, Reginster JY
Arthritis Res Ther 2015 Nov 30;17:346. doi: 10.1186/s13075-015-0807-y. PMID: 26620999Free PMC Article
Clinical and radiographic disease course of hand osteoarthritis and determinants of outcome after 6 years.
Bijsterbosch J, Watt I, Meulenbelt I, Rosendaal FR, Huizinga TW, Kloppenburg M
Ann Rheum Dis 2011 Jan;70(1):68-73. Epub 2010 Aug 24 doi: 10.1136/ard.2010.133017. PMID: 20736393

Recent systematic reviews

Efficacy of corticosteroids for hand osteoarthritis - a systematic review and meta-analysis of randomized controlled trials.
Estee MM, Cicuttini FM, Page MJ, Butala AD, Wluka AE, Hussain SM, Wang Y
BMC Musculoskelet Disord 2022 Jul 13;23(1):665. doi: 10.1186/s12891-022-05619-9. PMID: 35831847Free PMC Article
A systematic search and critical review of measures of disability for use in a population survey of hand osteoarthritis (OA).
Dziedzic KS, Thomas E, Hay EM
Osteoarthritis Cartilage 2005 Jan;13(1):1-12. doi: 10.1016/j.joca.2004.09.010. PMID: 15639631

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2022
      UK NICE Guideline NG226, Osteoarthritis in over 16s: diagnosis and management, 2022

    Consumer resources

    Reviews

    Related information

    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
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